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Challenge missions involve specific scoring objectives, such as holding out against progressive waves of enemies. The rewards may be experience, gold, and, for some missions in Guild Wars Factions, Luxon or Kurzick faction points, depending on completion and mission. You will see personal bests and high scores displayed within the game. In the Nightfall challenge missions it is possible to obtain the items required to change heroes' armor art, the probability of obtaining these items is suspected to increase with higher scores, however it is possible to obtain them even with low scores.

Campaign Region Challenge Mission Reward
Core The Battle Isles Zaishen Challenge Balthazar Faction
Zaishen Elite
Factions Kaineng City Dragon's Throat Gold, XP
Echovald Forest Altrumm Ruins Kurzick Faction, Gold, XP
Amatz Basin
The Jade Sea Zos Shivros Channel Luxon Faction, Gold, XP
The Aurios Mines
Nightfall Kourna Dajkah Inlet Stolen Sunspear Armor, Gold, XP
The Desolation Remains of Sahlahja Ancient Armor Remnants, Gold, XP
Realm of Torment The Shadow Nexus Mysterious Armor Pieces, Gold, XP
Eye of the North Central Transfer Chamber Glint's Challenge Cloth of the Brotherhood

In each of these locations, there is a Records NPC listing the current high scores.