Consider combining this skill with Soul Barbs. Not only will Soul Barbs deal damage for every hex cast after it, it counts as a hex for dealing damage with Signet of Suffering.
This signet combines particularly well with Signet of Twilight, as it also triggers on hexes, and removes any enchantments that might hinder the damage from Signet of Suffering beforehand.
The following table lists the number of hexes needed to achieve the maximum damage of 140: